吳莉玲 – 國立陽明交通大學生理學科暨研究所

吳莉玲

專任助理教授(醫學院微菌叢研究中心副主任)

02-2826-7365【實驗室網站https://wuliling1025.wixsite.com/gi-lab】

wuliling@nycu.edu.tw

消化道生理學、感染免疫學、分子病毒學、微生物學

學會會員、研究獲獎、研討會摘要/報告、專書

學歷

年度	學校名稱	學位
2008-2014	國立臺灣大學生理學科暨研究所	博士
2002	國立臺灣大學生理學科暨研究所	碩士

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經歷

年度	服務機關名稱	單位	職務
Sep,2023-迄今	國立陽明交通大學醫學院	醫學院微菌叢研究中心	副主任
Aug,2019-迄今	國立陽明大學醫學院	生理學科暨研究所	助理教授
Sep,2014-Jul,2019	國立臺灣大學	臨床醫學研究所	博士後研究
Jan,2002-Feb,2008	國立臺灣大學	生理學科暨研究所	助教
Jan,2002-Feb,2004	康寧護專		兼任講師
Jan,1998-Dec,1999	台北榮民總醫院		兼任及專任研究助理

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代表著作

排序編號	著作名稱
	吳莉玲老師學術ORCID: 0000-0002-2293-6999
	Jie-Lun Ku, Jia-Rou Hsu, Yung-Tsung Li and Li-Ling Wu* (2024) Interplay Among IL1R1, Gut Microbiota, and Bile Acids in Metabolic Dysfunction-associated Steatotic Liver Disease: A Comprehensive Review. Journal of Gastroenterology and Hepatology (Accepted) (IF=4.1) (*Corresponding author)
	Chia-Sheng Chu, Hsiao-Ping Chen, Pin-Hung Lin, Chi-Chen Cheng, Ho-Yu Kuo, Pei-Han Fan, Wei-Hao Peng, and Li-Ling Wu* (2024) Interleukin-1R1 deficiency worsens hepatocellular carcinoma while gemcitabine treatment alleviates the hepatocellular carcinoma-induced increase in intra-hepatic immune cells. Journal of Gastroenterology and Hepatology 2024 Jul 15. doi: 10.1111/jgh.16674. Epub ahead of print. (IF=4.1) (*Corresponding author)
	Yu-Li Lo, Ching-Yao Li, Tsui-Fen Chou, Ching-Ping Yang, Li-Ling Wu*, Chun Jung Chen, Yih-Hsin Chang (2024) Exploring in vivo combinatorial chemo-immunotherapy: Addressing p97 suppression and immune reinvigoration in pancreatic cancer with tumor microenvironment-responsive nanoformulation. Biomed Pharmacother.175: 116660. (IF=7.5)
	Yung-Ni Lin, Jia-Rou Hsu, Chih-Lin Wang, Yi-Chen Huang, Chun-Ying Wu, and Li-Ling Wu* (2024) Nuclear factor interleukin 3 and metabolic dysfunction-associated fatty liver disease development. Nature communication biology. 24;7(1):897 (IF=5.9)(*Corresponding author)
	Chia-Sheng Chu and Li-Ling Wu. (2024) Macrophages and Myeloid-derived suppressor cells in the Tumor Microenvironment of Hepatocellular Carcinoma: Insights into Molecular Pathways, Immunometabolism Processes, and Implications for Immunotherapy. IntechOpen book chapter (Accepted) DOI: 10.5772/intechopen.1005161 (Corresponding author)
	Yi-Chen Huang, Pin Hao Ko, and Li-Ling Wu * (2024) Age-dependent effects of acute stress on the behavior, blood parameters, immunity, and enteric nerves of mice. Behavioural Brain Research.2024 Mar 12;461:114848(*Corresponding author)
	Cheng-Hao Kuo, Li-Ling Wu, Hsiao-Ping Chen, Jun Yu and Chun-Ying Wu (2024) Direct effects of alcohol on gut-epithelial barrier: Unraveling the disruption of physical and chemical barrier of the gut-epithelial barrier that compromises the host-microbiota interface upon alcohol exposure. Journal of Gastroenterology and Hepatology.2024 Jul;39(7):1247-1255.
	Huey-Huey Chua, Ya-Hui Chen, Li-Ling Wu, Hung-Chih Yang, Chia-Ray Lin, Huey-Ling Chen, Jia-Feng Wu, Mei-Hwei Chang, Pei-Jer Chen, and Yen-Hsuan Ni. (2023) Antagonism between Gut Ruminococcus gnavus and Akkermansia muciniphila Modulates the Progression of Chronic Hepatitis B. Cellular and Molecular Gastroenterology and Hepatology.2024;17(3):361-381. (Co-First author)*(IF=8.797)
	Yung-Tsung Li, Hui-Lin Wu, and Li-Ling Wu (2023) Isolation of Murine Hepatic Myeloid Cells with High Yield and Purity Using Immunomagnetic Beads for Subset Analysis. STAR Protoc. 2023 Sep 22;4(4):102592 DOI: 10.1016/j.xpro.2023.102592 IF=1.48(*Corresponding author)
	Tzi-Yuan Wang, King-Siang Goh, Liang-Jong Wang,Li-LingWu, Feng-Yu Wang, Yu-Wei Wu. (2023) Long-Read Genome Sequencing of Abscondita cerata (Coleoptera: Lampyridae), the Endemic Firefly of Taiwan. Zoological Studies 62 (Accepted) IF=2.058
	Li-LingWu, Ting-ShuoHuang, Yu-ChiauShyu, Chih-LinWang, Hurng-YiWang, Pei-JerChen.Gut microbiota in the innate immunity against hepatitis B virus — implication in age-dependent HBV clearance. Current Opinion in Virology. Current Opinion in Virology,2021；49:194-202. IF=7.09
	Pin-Hung Lin, Chieh-Yu Liang, Bing-Yu Yao, Hui-Wen Chen, Ching-Fu Pan, Li-Ling Wu, Yi-Hsuan Lin,Yu-Sung Hsu, Yu-Han Liu, Pei-Jer Chen, Che-Ming Jack Hu, and Hung-Chih Yang.(2021) Robust induction of TRMs by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses. Molecular Therapy-Methods& Clinical Development. 21, 299-314. IF=4.533 (SCImago Journal Rank (SJR):* 1.872%)* (http://creativecommons.org/licenses/by-nc-nd/4.0/).
	Jau-Hau Horng; Wei-Hsiang Lin; Chang-Ru Wu; You-Yu Lin;Li-Ling Wu; Ding-Shinn Chen and pei-jer Chen (2020) HBV X protein-based therapeutic vaccine accelerates viral antigen clearance by mobilizing monocyte infiltration into the liver in HBV carrier mice. J Biomed Sci.;27(1):70. doi: 10.1186/s12929-020-00662-x IF=5.283
	Yu-Chen Pai, Li-Ting Weng, Shu-Chen Wei, Li-Ling Wu, David Q. Shih, Stephen R. Targan, Jerrold R. Turner and Linda Chia-Hui Yu. (2020) Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to IBD. Journal of Crohn s and Colitis, jjaa165. http://doi: 10.1093/ecco-jcc/jjaa165. IF=8.658
	Tung-Ching Ho, Er-Yea Wang, Kun-Huei Yeh, Yung-Ming Jeng, Jau-Hau Horng, Li-Ling Wu, Yi-Tzu Chen, Hsuan-Cheng Huang, Chia-Lang Hsu, Pei-Jer Chen, Shiou-Hwei Yeh, and Ding-Shinn Chen. (2020) Complement C1q mediates the expansion of periportal hepatic progenitor cells in senescence-associated inflammatory liver. Proc Natl Acad Sci U S A. 117 (12): 6717-6725 http:// doi: 10.1073/pnas.1918028117 IF 9.674(Journal Rank in Category(MULTIDISCIPLINARY SCIENCES):4/57, 7.02%)
	Li-Ling Wu, Hurng-Yi Wang, Pei-Jer Chen* (2019) Hydrodynamic HBV transfection in mouse models. International coalition to eliminate HBV(ICE-HBV). http://ice-hbv.org/protocol/hydrodynamic-hbv-transfection-in-mouse-models/
	Li-Ling Wu, Wei-Hao Peng, Hui-Lin Wu, Shi-Chuen Miaw, Shiou-Hwei Yeh, Hung-Chih Yang, Pei-Hsuan Liao, Jing-Shan Lin, Yan-Rong Chen, Yen-Tien Hong, Hurng-Yi Wang, Pei-Jer Chen and Ding-Shinn Chen, (2019) Ly6C⁺ Monocytes and Kupffer Cells Orchestrate Liver Immune Responses Against Hepatitis B Virus in Mice. Hepatology, 69(6):2364-2380. http://doi.org/10.1002/hep.30510 IF 17.425 (Gastroenterology & Hepatology:2/92, 6.52%) HEPATOLOGY HIGHLIGHTS \| Hepatology, VOL . 69, NO. 6, 2019; http://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.30775
	Li-Ling Wu, Hurng-Yi Wang, Pei-Jer Chen. (2017) Hydrodynamic HBV Transfection Mouse Model. Methods Mol Biol.1540:227-235. http://doi: 10.1007/978-1-4939-6700-1_19. IF 10.71( Journal Rank in Category 7988/10643745(Molecular Biology),0.605%)*
	Han-Hsuan Chou, Wei-Hung Chien, Li-Ling Wu, Chi-Hung Cheng, Chen-Han Chung, Jau-Haw Horng, Yen-Hsuan Ni, Hong-Tai Tseng, Dafei Wu, Xuemei Lu, Hurng-Yi Wang, Pei-Jer Chen, and Ding-Shinn Chen (2015) Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota. PNAS. 112(7):2175-80. http://doi.org/10.1073/pnas.1424775112 IF: 9.504 (MULTIDISCIPLINARY SCIENCES):5/64, 7.8125%)
	You-Yu Lin, Chieh Liu, Wei-Hung Chien, Li-Ling Wu, YongTao, Dafei Wu, Xuemei Lu, Chia-Hung Hsieh, Pei-Jer Chen, Hurng-Yi Wang, Jia-Horng Kao, Ding-Shinn Chen. (2014) New insights into the evolutionary rate of hepatitis B virus at different biological scales. Journal of virology. 89(7):3512-22. DOI: 10.1128/JVI.03131-14 IF: 4.368 (VIROLOGY): 8/35, 22.86%)
	Wei-Ting Kuo, Hsun-Yuan Yang, Chi-Yun Chen, Tsung-Chun Lee, Yin-Chung Au, Yen-Zhen Lu, Li-Ling Wu, Shu-Chen Wei, Yen-Hsuan Ni, John T Kung, Fuu Sheu, Long-Wei Lin, and Linda Chia-Hui Yu. (2015) LPS receptor subunits play antagonistic roles in epithelial apoptosis and colonic carcinogenesis. Cell Death and Differentiation, 22(10):1590-604. http://www.nature.com/articles/cdd2014240 IF: 8.0 (BIOCHEMISTRY & MOLECULAR BIOLOGY): 26/293, 8.87%)*
	Linda Yu, Yi-An Shih, Li-Ling Wu, Yang-Ding Lin, Wei-Ting Kuo, Wei-Hao Peng, Kuo-Shyan Lu, Shu-Chen Wei, and Yen-Hsuan Ni. (2014) Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis. American Journal of Physiology – Gastrointestinal and Liver Physiology, 307(8): G824-35. http://doi.org/10.1152/ajpgi.00070.2014 IF: 3.293 (PHYSIOLOGY): 22/83, 26.5%)*
	Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, Ching-Ying Huang, Yen-Hsuan Ni, Kuo-Shyan Lu, Jerrold R. Turner, and Linda C.H. Yu. (2014) Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-gamma. American journal of pathology, 184(8):2260-74. DOI: http://doi.org/10.1016/j.ajpath.2014.05.003 IF: 4.069 (PATHOLOGY): 13/79, 16.46%)*
	Tzu-Ling Chen, Shin Chen, Hsiu-Wei Wu, Tsung-Chun Lee, Yen-Zhen Lu, Li-Ling Wu, Yen-Hsuan Ni, Chin-Hung Sun, Wei-Hsuan Yu, Andre G Buret, and Linda Chia-Hui Yu. (2013) Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice. Gut Pathogens, 5(1):26. https://doi.org/10.1186/1757-4749-5-26 IF: 2.281 (MICROBIOLOGY: 71/119, 59.7%)*
	Li-Ling Wu, Hsin-Da Chiu, Wei-Hao Peng, Bor-Ru Lin, Kuo-Shyan Lu, Yen-Zhen Lu and Linda Chia-Hui Yu. (2011) Epithelial inducible nitric oxide synthase causes bacterial translocation by impairment of enterocytic tight junctions via intracellular signals of Rho-associated kinase and protein kinase C zeta. Critical Care Medicine, 39 (9), 2087-2098. IF: 6.312 (CRITICAL CARE MEDICINE: 4/27, 14.8%)*
	Chi-Chin Wu, Yen-Zhen Lu, Li-Ling Wu and Linda Chia-Hui Yu. (2010) Role of myosin light chain kinase in intestinal epithelial barrier defects in a rat model of bowel obstruction.BMC Gastroenterology, 10: 39-50. http://insights.ovid.com/pubmed?pmid=21552122 IF: 2.365 (GASTROENTEROLOGY & HEPATOLOGY:42/76, 55.3% )*
	Yih-Loong Lai, Li-Ling Wu, Tai-Yin Lin, and Chien-He Lin. (2009) Mast cells in citric acid-induced airway constriction and cough. Chinese Journal of Physiology, 52 (5 Supplement): 332-338. http://www.ncbi.nlm.nih.gov/pubmed/20359123 IF: 1.163 (PHYSIOLOGY:73/83, 97.95%)*
	Li-Ling Wu, Fung-Jou Lu and Yih-Loong Lai. (2004) Mast cells and reactive oxygen species in citric acid-induced airway constriction. Journal of applied physiology, 96: 1879-1885. DOI: 10.1152/japplphysiol.00999.2003 IF: 3.056 (SPORT SCIENCES:8/81, 9.88%)*

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五年內執行計畫

排序編號	年度	計畫名稱	單位	計畫期間
1	113-116	AKK菌及其相關代謝物，做為肝細胞癌之生物標記或輔助療法之研究 (1/4)	國科會共同計畫主持人	113/5/1~114/4/30
2	113	拓展全方位藥物試驗評估	產學合作案計畫主持人	113/4/1~114/3/31
3	113	國家人體微菌研究平台建置核心設施計畫–建置國家人體微菌研究合作與技術服務核心設施計畫	國科會共同計畫主持人	113/5/1~114/4/30
4	112-115	以腸道菌-腸-肝軸的觀點來探討可利舒散介入高脂飲食引起代謝相關脂肪性肝疾病:著重於腸漏、腸道菌群-膽汁酸-FXR訊息傳遞及免疫代謝重編程的分子機制	國科會計畫主持人	112/8/1~115/7/31
5	112-113	國家人體微菌研究平台建置核心設施計畫–建置國家人體微菌研究合作與技術服務核心設施計畫	國科會共同計畫主持人	112/5/1~113/4/30
6	112-113	小鼠動物模式之聚天試驗評估	產學合作案計畫主持人	112/5/1~113/1/31
7	112-114	細胞藥物篩檢試驗評估	產學合作案計畫主持人	112/3/1~114/2/28
8	112-112	FK506 結合蛋白5缺乏基因剔除鼠給予脂多醣誘導急性腎損傷對於調節腸道菌群組成和腸道屏障功能之調控機制及可能的治療策略	衛生福利部桃園醫院專題研究計畫共同計畫主持人	112/1/1~112/12/31
9	112-115	囊性纖維化蛋白的結構藥物設計	國家衛生研究院整合性醫藥衛生科技研究計畫共同計畫主持人	112/1/1-115/12/31
10	111-112	小鼠動物藥物試驗評估	產學合作案計畫主持人	111/8/1-112/2/28
11	111-112	腸道菌在脂多醣誘導的急慢性腎損傷之炎症反應和抗氧化之調控並探討 FKBP5所扮演的關鍵角色	科技部計畫主持人	111/8/1-112/7/31
12	111	核因子 IL-3(Nfil3)和腸道菌群在蛋氨酸-膽鹼缺乏飲食誘導的非酒精性脂肪肝疾病中的作用機制	臺北榮民總醫院嚴慶齡醫學研究中心研究計畫計畫主持人	111/1/1-111/12/31
13	110-113	緊密連接蛋白ZO-1在炎症性疾病中調節黏膜癒合：機制探討與治療應用	科技部共同計畫主持人	110/11/1-113/7/31
14	110-111	小鼠動物藥物試驗評估	產學合作案計畫主持人	110/11/1-111/7/31
15	110-111	藥物動物試驗評估	產學合作案計畫主持人	110/5/1-111/1/31
16	110	VSL#3益生菌透過腸-腎軸線改善高脂飲食誘導的肥胖症以及慢性腎臟病之調控機制及可能的預防與治療策略	衛生福利部桃園醫院專題研究計畫共同計畫主持人	110/1/1-110/12/31
17	110	腸道菌與高脂飲食誘導的肥胖症以及代謝相關脂肪性肝病之間的相互作用：探討FKBP5所扮演的關鍵角色	臺北榮民總醫院嚴慶齡醫學研究中心研究計畫計畫主持人	110/1/1-110/12/31
18	109	藥物細胞試驗評估	產學合作案計畫主持人	109/8/1-110/2/1
19	109-112	Ｂ型肝炎病毒清除之年齡依賴性取決於腸道菌群的代謝與免疫調控	科技部協同計畫主持人	109/8/1-112/7/31
20	109-112	水溶性環氧化物水解酶在肥胖相關代謝異常之病生理功能：造血重編程與腸道菌相之角色	科技部共同計畫主持人	109/8/1-112/7/31
21	108-111	腸道菌在肝臟先天免疫反應中對抗B型肝炎病毒所扮演的角色及其調控機制之探討	科技部計畫主持人	108/10/1-111/9/30

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實驗室成員

職稱/ 學位	姓名
博士班	朱家聲（跨領域醫學博士學程）
碩士班	范沛涵、郭賀喻、蔡鎧鴻、蔡睿辰
碩士班畢業	廖堉甄、陳嘉晏、賴世婕、黃怡禎、陳思葶、王芷琳、林咏霓、許家柔
大學部	大學生：古杰倫（醫學系）、朱宸頡（醫學系）、簡芃欣（藥學系）、鄭祺臻（醫師科學家）、孫悅恩（醫學系）、郭正浩（醫學系）
暑期實習生	吳宥萱、王姿云 (Serena Wang)、許媛雯、吳珮瑄、鄭茹憶、黄柏竣

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實驗室活動

實驗室網站 https://wuliling1025.wixsite.com/gi-lab

2024年

2023年

2022年

2021年

2020年

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研究方向

本實驗室研究領域是以腸胃道生理學為主，目前研究計畫主要探討腸道菌透過腸-肝軸如何影響B型肝炎病毒持續性或清除感染之預後，主要目的是釐清其於免疫系統中innate myeloid cell和lymphoid cell所扮演的角色，以及腸道屏障功能的完整性，以期望了解腸道菌及其代謝產物如何影響肝臟免疫反應的完整訊息及機制，藉由此研究將有助於開發預防和治療先天免疫細胞相關肝病新穎和創新的策略，以期望未來可藉由細胞免疫療法來重新改編宿主的抗病毒免疫力，進而達成全面清除B型肝炎病毒，對未來Ｂ型肝炎的預防與治療提供新契機及新發現。

本實驗室透過疾病的動物模式及細胞分子層次，利用in vivo及in vitro的實驗來完整及有系統的探討腸-肝軸 (gut-liver axis) 相關研究為主，目前實驗室已建立HBV-HDI mice， Germ free mice, CRISPR-Cas9 TLR4 mice, TLR4 mutant mice, intestinal obstruction等小鼠模式，並配合多種分子生物學的實驗技術，以進一步探討細胞分子的作用機轉。實驗技術包括：

(1) Intestinal, liver function and phenotype assay: ALT, AST, HBsAg, HBeAg, Anti-HBs, Anti-Hbe, Anti-Hbc, HBV DNA assay, bacterial translocation, H&E staining, isolation of total liver parenchymal and nonparenchymal cells and flow cytometry analysis.

(2) Biochemical technology: immunofluorescent staining, surface and intracellular staining for flow cytometric analysis and sorting, fluorescent in situ hybridization, ELISPOT, Adoptive transfer, hydrodynamic injection.

(3) Molecular biotechnology: RNA and DNA extraction, RT-PCR, siRNA knockdown, site directed mutagenesis, plasmid transfection, bacterial 16S rDNA sequencing, Temporal temperature gradient gel electrophoresis (TTGE), Southern Bolt, western blotting, Northern blotting. Gene expression profiles using NanoString or RNAseq.

歡迎具有積極主動、學習熱忱的同學加入腸胃道生理學的研究行列。

～愛因斯坦～

好奇心是科學工作者產生無窮的毅力和耐心的源泉！

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學會會員、研究獲獎、研討會摘要/報告、專書

學會會員 :

中國生理學會(Chinese Physiological Society)

研究獲獎 :

(1) 科技部補助大專校院延攬特殊優秀人才獎，臺灣，2019-2020。

(2) 沈力揚教授醫學教育獎，臺灣，2019。

(3) 國際B型肝炎會議『博士後出國開會補助』，臺灣，2019。

(4) 財團法人傑出人才基金會『博士後出國開會補助』，臺灣，2018。

(5) 國際B型肝炎會議『博士後出國開會補助』，美國，2018。

(6) 國際B型肝炎會議研討會『傑出海報獎』第一名，義大利，2018。

(7) 國際B型肝炎會議『博士後出國開會補助』，美國，2017。

(8) 國際B型肝炎會議研討會『傑出海報獎』第一名，美國，2017。

(9) 國立台灣大學『優秀研究生優秀著作獎』佳作，臺灣，2015。

(10) 第三十屆全國生物醫學聯合學術年會『口頭論文競賽』傑出論文獎，臺灣，2015。

(11) 第三十屆全國生物醫學聯合學術年會『口頭論文競賽』第一名，臺灣，2015。

(12) 第二十九屆全國生物醫學聯合學術年會『口頭論文競賽』第一名，臺灣，2014。

(13) 第一屆國立台灣大學『分子生醫影像攝影競賽』佳作，臺灣，2012。

(14) 國立台灣大學『優秀研究生優秀著作獎』佳作，臺灣，2012。

(15) 第二十七屆全國生物醫學聯合學術年會『壁報論文競賽』佳作，臺灣，2009。

(16) 第二十五屆全國生物醫學聯合學術年會『口頭論文競賽』第一名，臺灣，2010。

(17) 美國消化道疾病國際性研討會『傑出海報獎』，美國，2009。

(18) 第二十四屆全國生物醫學聯合學術年會『壁報論文競賽』第一名，臺灣，2009。

產學合作計畫 :

HBV藥物細胞試驗評估，執行期間:2020/8/1-2021/2/1。

研討會摘要 :

1	Yu-Jen Liao, Luen-Kui Chen, Chi-Chang Juan and Li-Ling Wu* (2020) THE INTERPLAY BETWEEN GUT MICROBIOTA AND HIGH-FAT-DIET-INDUCED INSULIN RESISTANCE AND SUBSEQUENT DEVELOPMENT OF OBESITY: POTENTIAL ROLE OF FKBP5. Gastroenterology 158(6), S-1220. DOI: https://doi.org/10.1016/S0016-5085(20)33708-2
2	Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, Ching-Ying Huang, Yen-Hsuan Ni, Kuo-Shyan Lu, Jerrold R. Turner, Linda C.H. Yu* (2014fu) Gut bacterial endocytosis is dependent on MLCK-activated brush border fanning by IFN. Gastroenterology 146 (5), S-697. DOI: http://doi.org/10.1016/S0016-5085(14)62533-6
3	Wei-Ting Kuo, Hsun-Yuan Yang, Chi-Yun Chen, Tsung-Chun Lee, Yen-Zhen Lu, Li-Ling Wu, Yen-Hsuan Ni, Shu-Chen Wei, Linda C.H. Yu* (2014) Opposing roles of CD14 and TLR4 in bacterial LPS-induced colonocytic apoptosis. Gastroenterology 146(5), S-294. DOI: http://doi.org/10.1016/S0016-5085(14)61052-0
4	Li-Ling Wu , Wei-Ting Kuo, Wei-Hao Peng, Kuo-Shyan Lu, Yen-Hsuan Ni and Linda Chia-Hui Yu* (2012) Intestinal Epithelial Endocytosis of Commensal bacteria is dependent on phosphorylation of terminal web myosin by myosin light chain kinase in bowel obstruction. Gastroenterology 142 (5), Suppl 1, S-174. DOI: http://doi.org/10.1016/S0016-5085(12)60652-0
5	Li-Ling Wu , Wei-Ting Kuo and Linda Chia-Hui Yu*. (2011) Epithelial MLCK-Dependent Bacterial Endocytosis by Enterocytes Precedes Paracellular Bacterial Flux in Bowel Obstruction. Gastroenterology,140(5), S63-S64. DOI: http://doi.org/10.1016/S0016-5085(11)60259-X
6	Li-Ling Wu , Hsin-Da Chiu, Yen-Zhen Lu, and Linda Chia-Hui Yu*. (2010) Epithelial iNOS impairs tight junctions leading to bacterial translocation via PKCzeta activation and Rho/ROCK-dependent myosin light chain phosphorylation in obstructed guts. Gastroenterology 138 (5), Suppl 1, S-4. DOI: http://doi.org/10.1016/S0016-5085(10)60018-2
7	Li-Ling Wu , Ching-Ying Huang, Yen-Zhen Lu, and Linda Chia-Hui Yu*. (2009) Epithelial MLCK and iNOS are involved in mucosal barrier defects and bacterial translocation induced by ileal obstruction. Gastroenterology 136 (5), Suppl 1, A410. DOI: http://doi.org/10.1016/S0016-5085(09)61886-2

研討會發表 :

1	Yu-Chin Huang2#, Jia-Rou Hsu1#, Chia-Yen Chen1#, Wei-Hao Peng3, Der-Cherng Tarng4, and Li-Ling Wu*. FK506-Binding Protein 5 regulated the gut-kidney axis and exhibited a renal protective effect in acute kidney injury induced by lipopolysaccharide. APCN & KSN, June 13~16 2024. Coex, Seoul , Korea. (Oral presentation)
2	Chi-Chen Cheng, Hsiao-Ping Chen, He-Yu Kuo, Pei- Han Fan, Jie-Lun Ku, Cheng-Hao Kuo, Chun-Ying Wu, Li-Ling Wu*. CRISPR/Cas9-Mediated TLR4 Knockout Attenuates Hepatocellular Carcinoma Progression in Mice by Modulating the Kinetics of Myeloid-Derived Suppressor Cell Subsets. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Oral presentation)
3	Ho-Yu Kuo, Pei-Han Fan, Hsiao-Ping Chen, Chen-Hao Kuo, Kai-Hung Tsai, Jui-Chen Tsai, and Li-Ling Wu. TAURINE-MEDIATED MODULATION OF GUT MICROBIOTA AND INFLAMMATORY INTRAHEPATIC IMMUNE RESPONSE ATTENUATES FIBROSIS IN CDAHFD-INDUCED METABOLIC-ASSOCIATED STEATOHEPATITIS. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation) (論文傑出海報獎)
4	Cheng-Hao Kuo, Hsiao-Ping Chen, He-Yu Kuo, Pei-Han Fan, Li-Ling Wu, and Chun-Ying Wu. METABOLIC SWITCHING, GUT INTEGRITY AND HOST-MICROBIOTA INTERACTION IN ALCOHOL-INDUCED INTESTINAL INJURY. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation)
5
6	Pei-Han Fan, He-Yu Kuo, Hsiao-Ping Chen, Kai-Hung Tsai, Jui-Chen Tsai, and Li-Ling Wu* BETAINE ALLEVIATES GUT BARRIER INFLAMMATION AND Ly6C MONOCYTES AND KUPFFER CELLS ORCHESTRATE LIVER IMMUNE RESPONES PREVENTS DSS INDUCED COLITIS AND ASSOCIATED LIVER INJURY. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation)
7	Chia-Sheng Chu, Hsiao-Ping Chen, Pin-Hung Lin, Chi-Chen Cheng, He-Yu Kuo, Pei-Han Fan, Chun-Ying Wu and Li-Ling Wu*. ROLE OF IL-1R1 AND MYELOID-DERIVED SUPPRESSOR CELLS IN HEPATOCELLULAR CARCINOMA PROGRESSION AND IMMUNOTHERAPY. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation)
8	Chia-Sheng Chu, Hsiao-Ping Chen, Pin-Hung Lin, Chi-Chen Cheng, He-Yu Kuo, Pei-Han Fan, Chun-Ying Wu and Li-Ling Wu*. HCC are exacerbated by IL-1R1 deficiency and Myeloid-derived Suppressor Cell in Tumor Immunotherapy. APASL 2024-3-27~31. Kyoto, Japan. (Poster presentation)
9	Pei-Ching Chang, Jiunn-Chang Lin, Kai-Ting Yu, Yung-Chih Hong, Tze-Yun Hu, Kai-Hsiang Hsu, Kate Hua, Chih-Sin Hsu, Tai-Ming Ko, Li-Ling Wu, Chun-Ying Wu, Yan-Hwa Wu Lee. Single-cell profiling of HBV-associated hepatocellular carcinoma reveals novel HBV-related tumor-immune interaction. AASLD 2024-11-15~19, San Diego, CA, USA. (Poster presentation)
10	Chih-Lin Wang, Jie-Lun Ku, He-Yu Kuo, Chen-Jie Zhu, Yung-Ni Lin, Jia-Rou Hsu and Li-Ling Wu*. Betaine improved CDAHFD Diet-induced NAFLD by enhancing gut barrier function and modulating intrahepatic inflammation and immunity via activation of the NLRP3/mTOR signaling pathway. 第六屆台灣微菌聯盟學術年會, 2023. 機構:國立陽明大學生理所 (論文優等第一名)
11	Jia-Rou Hsu, Jie-Lun Ku, Chih-Lin Wang, Yung-Ni Lin, Yi-Chen Huang, Chun-Ying Wu, Li-Ling Wu. Cholestyramine Alleviated High-Fat Diet-Induced MAFLD through Regulating Metabolic Reprogramming of the Gut Microbiota with Alterations in Bile Acid profile and Hepatic Immunity. 第六屆台灣微菌聯盟學術年會, 2023. 機構:國立陽明大學生理所 (論文優等第二名)
12	Chih-Lin Wang, Jie-Lun Ku, He-Yu Kuo, Chen-Jie Zhu, Yung-Ni Lin, Jia-Rou Hsu and Li-Ling Wu*. Betaine reduces CDAHFD Diet-induced MAFLD by enhancing gut barrier function and modulating intrahepatic inflammation and immunity via activation of the NLRP3/mTOR signaling pathway. 第37屆生物醫學聯合學術年會,2023. 機構:國立陽明大學生理所(論文優等獎)
13	Chih-Lin Wang, Jie-Lun Ku, He-Yu Kuo, Chen-Jie Zhu, Yung-Ni Lin, Jia-Rou Hsu and Li-Ling Wu*. Betaine alleviates CDAHFD Diet-induced MAFLD by improving gut barrier function and regulating intrahepatic inflammation and immunity via activation of NLRP3/mTOR signaling pathway. Digestive Disease Week® (DDW2023), Chicago, 2023. 機構:國立陽明大學生理所 (傑出海報獎)
14	Chi-chen Cheng, Hsiao-Ping Chen, Jie-Lun Ku, Jia-Rou Hsu, Yung-Ni Lin, Li-Ling Wu* and Chun-Ying Wu*. Hight fat diet drives fatty liver associated liver cancer exhibit gut microbiota-deepened alterations in NLRP3 signaling promotes the development of a novels sleeping beauty transponson-mediated Nras knock in induced HCC in mice, Digestive Disease Week® (DDW2023), Chicago, 2023. 機構:國立陽明大學生理所 (傑出海報獎)
15	Chi-chen Cheng, Hsiao-Ping Chen, Jie-Lun Ku, Jia-Rou Hsu, Yung-Ni Lin, Li-Ling Wu* and Chun-Ying Wu*. Germ-free mice exhibit profound gut microbiota-dependent alterations in gut endocannabinoidome signaling and intrahepatic immune system accelerate the development of a new spontaneous nonalcoholic steatohepatitis-hepatocellular carcinoma generated by hydrodynamic transfection mouse.第37屆生物醫學聯合學術年會,2023. 機構:國立陽明大學生理所(Poster presentation)
16
17	Chi-chen Cheng, Hsiao-Ping Chen, Jie-Lun Ku, Jia-Rou Hsu, Yung-Ni Lin, Li-Ling Wu* and Chun-Ying Wu*. High-fat diet and a Novel Transposon-mediated Nras Knock-in Produced HCC with Gut microbiome-dependent alterations in NLRP3 signaling. 第六屆台灣微菌聯盟學術年會, 2023. 機構:國立陽明大學生理所(Poster presentation)
18	Yung-Ni Lin; Chih Lin Wang; Jia-Rou Hsu; Li-Ling Wu, Gender differences in gut microbiota regulation-mediated bile acid metabolism in high-fat associated MAFLD through the Nfil3-FXR-FGF15 signaling pathway in mice. Digestive Disease Week® (DDW2023), Chicago, 2023. 機構:國立陽明大學生理所 (Poster presentation)
19	Yung-Ni Lin; Chih Lin Wang; Jia-Rou Hsu; Chun-Ying Wu, Li-Ling Wu, Gut microbiome regulated bile acid metabolism during high-fat diet-associated MAFLD through the Nfil3-FXR-FGF-15 signaling pathway in different gender mice. 第六屆台灣微菌聯盟學術年會, 2023. 機構:國立陽明大學生理所(Poster presentation)
20	Yung-Ni Lin; Chih Lin Wang; Jia-Rou Hsu; Li-Ling Wu, Nuclear factor, interleukin 3 determines sex-specific differences in gut microbiota regulation-mediated bile acid metabolism in high-fat diet-associated MAFLD. 第37屆生物醫學聯合學術年會,2023. 機構:國立陽明大學生理所(Poster presentation)
21	Jia-Rou Hsu, Jie-Lun Ku, Chih-Lin Wang, Yung-Ni Lin, Yi-Chen Huang, Li-Ling Wu*, Cholestyramine ameliorated High-Fat Diet-Induced MAFLD by Regulating Metabolic Reprogramming of the Gut Microbiota and Alterations in Bile Acid Profile and Hepatic Immunity. 第37屆生物醫學聯合學術年會,2023. 機構:國立陽明大學生理所(Poster presentation)
22	Chih-Lin Wang, Jie-Lun Ku, Chen-Jie Zhu, Chia-Yen Chen, Shih-Chieh Lai, Yi-Chen Huang, Yung-Ni Lin, Jia-Rou Hsu, Zi-Yun Wang and Li-Ling Wu*, GUT MICROBIOME-RELATED EFFECTS OF BETAINE IMPROVE NASH BY MODULATING LIVER IMMUNE RESPONSES IN CHOLINE-DEFICIENT, L-AMINO ACID-DEFINED DIET-FED MICE,第36屆生物醫學聯合學術年會,2022. 機構:國立陽明大學生理所(Poster presentation) (論文優等獎)
23	Yung-Ni Lin, Yi-Chen Huang, Pin Hao Ko, Wei-Ting Kuo, Yu-Chin Huang, Chih-Lin Wang, Jia-Rou Hsu, Chen-Jie Zhu, Zi-Yun Wang and Li-Ling Wu*, Metabolic modeling of gut microbiota in high-fat diet induced nonalcoholic steatohepatitis through barrier dysfunction and shaping of intrahepatic immunity are ameliorated by VSL#3 supplementation,第36屆生物醫學聯合學術年會,2022. 機構:國立陽明大學生理所(Poster presentation)
24	Chia-Yen Chen, Jia-Rou Hsu, Shih-Chieh Lai, Man-Hau Ho, Pin-Hao Ko, Yu-Chin Huang, Yi-Chen Huang and Li-Ling Wu*, The Deficiency of FKBP5 Inhibited Lipopolysaccharide-induced Acute Kidney Injury: Regulates Gut Barrier via NFκB Pathway. 第36屆生物醫學聯合學術年會,2022. 機構:國立陽明大學生理所(Poster presentation)
25	Suu-Ting Chen, Yung-Tsung Li, Po-Hsi Huang, Hui-Lin Wu and Li-Ling Wu*, Evaluating the Effect of An Active Protein Component from Mushrooms on the Gut-Liver Axis and the Feasibility of Using It As An Adjunct Therapy For Chronic Hepatitis B. 第36屆生物醫學聯合學術年會,2022. 機構:國立陽明大學生理所(Poster presentation)
26	Yi-Chen Huang, Yu-Jen Liao, Chia-Yen Chen, Shih-Chieh Lai, Chien Pong Hsin and Li-Ling Wu*, Age-Related Shift in Gut Microbiota Contribute to Alteration of Gut Cannabinoid Type 1 Receptor and Myeloid Cells Innate Immune Response in Acute Restraint Stress Mice.第36屆生物醫學聯合學術年會,國立陽明交通大學,2022. 機構:國立陽明大學生理所(Poster presentation)
27	Lin, Yung-Ni; Huang, Yi-Chen; Huang, Yu-Chin; Wang, Chih Lin; Hsu, Jia-Rou; Ku, Jie-Lun; Zhu, Chen-Jie; Hsin, Chien-Pong; Wang, Zi-Yun; Li-Ling Wu, Probiotic VSL#3 Improved High Fat Diet-induced Nonalcoholic Steatohepatitis Through Reconstruction Of Gut Microbiota Compositions, Enhanced Gut Barrier Function And Sharping Of Intrahepatic Immunity.第36屆生物醫學聯合學術年會,2022. 機構:國立陽明大學生理所(Poster presentation)
28	Chih-Lin Wang, Jie-Lun Ku, Chen-Jie Zhu, Chia-Yen Chen, Shih-Chieh Lai, Yi-Chen Huang, Yung-Ni Lin, Jia-Rou Hsu, Zi-Yun Wang and Li-Ling Wu*, GUT MICROBIOME-RELATED EFFECTS OF DIETARY SUPPLEMENTATION WITH BETAINE IMPROVE NONALCOHOLIC STEATOHEPATITIS BY MODULATING LIVER IMMUNE RESPONSES IN CDAHFD DIET-FED MICE,39th Congress of the International Union of Physiological Sciences (IUPS),北京,2022. 機構:國立陽明大學生理所(Poster presentation)
29	Chih-Lin Wang, Jie-Lun Ku, Chen-Jie Zhu, Chia-Yen Chen, Shih-Chieh Lai, Yi-Chen Huang, Yung-Ni Lin, Jia-Rou Hsu, Zi-Yun Wang and Li-Ling Wu*, Gut microbiome-related effects of Betaine improve nonalcoholic steatohepatitis by modulating hepatic natural killer cells and macrophage orchestrate liver immune responses in choline-deficient, L-amino acid-defined, high-fat diet-fed mice, Digestive Disease Week® (DDW2022),San Diego, CA + Virtual, 2022. 機構:國立陽明大學生理所(Poster presentation) (傑出海報獎)
30	Yan-Rong Chen, Suu-Ting Chen, Chih-Lin Wang, Yung-Tsung Li, Hui-Lin Wu, Li-Ling Wu, BET Supplementation Contributes to Hepatitis B Viral Clearance in a Hydrodynamic Injection Mouse Model.第36屆生物醫學聯合學術年會, 2022. 機構:國立陽明大學生理所(Poster presentation) (論文佳作獎)
31	Yung-Ni Lin, Yi-Chen Huang, Pin Hao Ko, Wei-Ting Kuo, Yu-Chin Huang, Chih-Lin Wang, Jia-Rou Hsu, Chen-Jie Zhu, Zi-Yun Wang and Li-Ling Wu*, Metabolic modeling of gut microbiota in high-fat diet induced nonalcoholic steatohepatitis through barrier dysfunction and shaping of intrahepatic immunity are ameliorated by VSL#3 supplementation, Digestive Disease Week® (DDW2022),San Diego, CA + Virtual, 2022. 機構:國立陽明大學生理所(Poster presentation) (傑出海報獎)
32	Chia-Yen Chen, Jia-Rou Hsu, Shih-Chieh Lai, Man-Hau Ho, Pin-Hao Ko, Yu-Chin Huang, Yi-Chen Huang and Li-Ling Wu*, FK506 Binding Protein 5 deficiency regulates gut microbiota and gut barrier against lipopolysaccharide-induced acute kidney injury in mice. Digestive Disease Week® (DDW2022), San Diego, CA + Virtual, 2022. 機構:國立陽明大學生理所(Poster presentation)
33	Yu-Jen Liao, Luen-Kui Chen, Pin Hao Ko, Wei-Hao Peng, Shih-Chieh Lai, Chia-Yen Chen, Yi-Chen Huang, Shen-Cheng Jin, Chi-Chang Juan and Li-Ling Wu*, FK506 Binding Protein 5 deficiency Against Obesity-induced Gut Dysbiosis Disrupted Gut Epithelial Barrier and Regulates Gut-Liver Immunity,2021 Digestive Disease Week® (DDW),Virtual, 2021. 機構:國立陽明大學生理所(Poster presentation) (傑出海報獎)
34	Li-Ling Wu, Shih-Chieh Lai, Chia-Yen Chen, Yu-Jen Liao, Pin Hao Ko, Yi-Chen Huang, Shen-Cheng Jin, and Yi-Hsuan Lee, FK506 Binding Protein 5 Deficiency regulates Gut microbiota and Serotonin Influences Gut-Brain Axis.,2021 Digestive Disease Week® (DDW), Virtual ePoster, 2021. 機構:國立陽明大學生理所 (Poster presentation)
35	Yu-Jen Liao, Luen-Kui Chen, Chi-Chang Juan and Li-Ling Wu, Gastroenterology 158(6), S-1220., Digestive disease week, Chicago,2020. 機構:國立陽明大學生理所. (Poster presentation)
36	Yung-Tsung Li, Chun-Jen Liu, Li-Ling Wu, Li-Feng Lin, Hui-Chu Tu, Pei-Jer Chen, Ding-Shinn Chen, Hui-Lin Wu., Metastatic tumor antigen 1, an HBx-interacting protein, stabilizes the 3′ UTR of MYC RNA and protects it from let-7-mediated repression.,2019 International HBV Meeting., Melbourne, 2019. 機構:國立陽明大學生理所 (Poster presentation)

專書 :

1	Li-Ling Wu, Hurng-Yi Wang, Pei-Jer Chen*. (2017) Hydrodynamic HBV Transfection Mouse Model. Hepatitis B Virus Methods and Protocols-Methods in Molecular Biology (ISBN: 978-1-4939-6698-1). New York, USA: Springer New York. Methods Mol Biol. 2017;1540: 227-235.
2	Yih-Loong Lai, Li-Ling Wu, L. C. Lai, Human respiration physiology, Gold name Book Publishers, ISBN：978-986-6575-88-4, Taipei, Taiwan, 2013
3	Yih-Loong Lai, Linda Chia-Hui Yu, Li-Ling Wu, Wan-fang Liu, Zi-Yin Chen, Shyh-Jong Wu, Medical Physiology, Ho-Chi Book Publishers, ISBN 978-986-157-570-4,Taipei, Taiwan, 2008
4	Yih-Loong Lai, Yuan-Feen Tsai, M. C. Hu, Li-Ling Wu, Ying-Jui Ho, Crown-State Zhu, Yi-lin Xie, Ya-Hui Ku, Wei-Yao Wang, Yi-Ren Wang, Human physiology: mechanisms of body function, Yi-Xuan Book Publishers, ISBN：986-157-252X,Taipei, Taiwan, 2006
5	Li-Ling Wu, Yi-lin Xie et al., New Medical Physiology (Revised Edition) Ho-Chi Book Publishers, ISBN 9812594647,Taipei, Taiwan, 2005
6	Li-Ling Wu, Crown-State Zhu, Ying-Jui Ho, Physiology Essentials, Yi-Xuan Book Publishers, ISBN 9576167108,Taipei, Taiwan, 2003
7	Li-Ling Wu, Ying-Jui Ho, Physiology proficient, Yi-Xuan Book Publishers, ISBN 9576166799,Taipei, Taiwan, 2002

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