高毓儒

兼任教授

02-2826-7080(此為生理所辦公室電話,若有重要來電將協助轉介訊息。)

yc-chiou@nycu.edu.tw (此為本單位職員邱先生的mail,若有重要來信將協助轉介訊息。)

呼吸生理學、分子生物學、急重病醫學、醫學流行病學、臨床醫學研究

學歷

年度學校名稱學位
1980Bachelor of Science, Department of Biology, Tunghai University, R.O.CBS
1989Department of Physiology and Biophysics, University of Kentucky, KentuckyPHD

經歷

年度服務機關名稱單位職務
1989-1991美國凱斯西儲大學醫學院呼吸重症中心研究員
1991-1997國立陽明大學醫學院生理學研究所副教授
2008-2011行政院國科會生物處形態及生理醫學學門召集人
2008-2022/2國立陽明交通大學醫學院急重症醫學研究所教授
1997-2022/2國立陽明交通大學醫學院生理學科暨研究所教授

代表著作

排序編號著作名稱
1Chen PK, Shih CC, Lin FC, Perng DW, Chou KT, Kou YR*, Ko HK. Prolonged use of noninvasive positive pressure ventilation after extubation among patients in the intensive care unit following cardiac surgery: The predictors and its impact on patient outcome. Sci Rep. 2019 Jul 2;9(1):9539.
2Su KC, Ko HK, Chou KT, Hsiao YH, Su VY, Perng DW, Kou YR*. An accurate prediction model to identify undiagnosed at-risk patients with COPD: a cross-sectional case-finding study. NPJ Prim Care Respir Med. 2019 May 28;29(1):22.
3Chen YC, Yu WK, Ko HK, Pan SW, Chen YW, Ho LI, Bien MY, Wang JH, Chan YJ, Kou YR*. Post-intensive care unit respiratory failure in older patients liberated from intensive care unit and ventilator: The predictive value of the National Early Warning Score on intensive care unit discharge. Geriatr Gerontol Int. 2019 Apr;19(4):317-322.
4Lin AH, Liu MH, Ko HK, Perng DW, Lee TS, Kou YR*. Menthol Cigarette Smoke Induces More Severe Lung Inflammation Than Non-menthol Cigarette Smoke Does in Mice With Subchronic Exposure – Role of TRPM8. Front Physiol. 2018 Dec 18;9:1817.
5Hsiao YH, Tseng CM, Su KC, Chen WC, Wu MT, Wu YC, Chang SC, Lee YC, Kou YR*, Perng DW. Glycopyrronium bromide inhibits lung inflammation and small airway remodeling induced by subchronic cigarette smoke exposure in mice. Respir Physiol Neurobiol. 2018 Feb;249:16-22.
6Pan SW, Yen YF, Kou YR, Chuang PH, Su VY, Feng JY, Chan YJ, Su WJ. The Risk of TB in Patients With Type 2 Diabetes Initiating Metformin vs Sulfonylurea Treatment. Chest. 2018 Jun;153(6):1347-1357.
7Su KC, Kou YR, Lin FC, Wu CH, Feng JY, Huang SF, Shiung TF, Chung KC, Tung YH, Yang KY, Chang SC. A simplified prevention bundle with dual hand hygiene audit reduces early-onset ventilator-associated pneumonia in cardiovascular surgery units: An interrupted time-series analysis. PLoS One. 2017 Aug 2;12(8):e0182252.
8Pan SW, Yen YF, Kou YR, Chuang PH, Feng JY, Chan YJ, Su WJ. The impact of cancer development on the risk of mycobacterial diseases among rheumatoid arthritis patients. Epidemiol Infect. 2017 Sep;145(12):2482-2490.
9Lin CH, Jeng MJ, Yang YC, Hsiao YH, Kou YR*. Comparison of different dosing strategies of intratracheally instilled budesonide on meconium injured piglet lungs. Pediatr Pulmonol. 2017 Jul;52(7):891-899.
10Lin AH, Liu MH, Ko HB, Perng DW, Lee TS, Kou YR*. Inflammatory Effects of Menthol vs. Non-menthol Cigarette Smoke Extract on Human Lung Epithelial Cells: A Double-Hit on TRPM8 by Reactive Oxygen Species and Menthol. Front Physiol. 2017 Apr 27;8:263.
11Tsao PC, Lee YS, Jeng MJ, Hsu JW, Huang KL, Tsai SJ, Chen MH, Soong WJ, Kou YR*. Additive effect of congenital heart disease and early developmental disorders on attention-deficit/hyperactivity disorder and autism spectrum disorder: a nationwide population-based longitudinal study. Eur Child Adolesc Psychiatry. 2017 Nov;26(11):1351-1359.
12Liu MH, Lin AH, Ko HK, Perng DW, Lee TS, Kou YR*. Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol. Front Physiol. 2017 Mar 31;8:193.
13Su KC, Chou KT, Hsiao YH, Tseng CM, Su VY, Lee YC, Perng DW, Kou YR*. Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study. BMC Infect Dis. 2017 Apr 8;17(1):252.
14Yang CH, Shen YJ, Lai CJ, Kou YR*. Inflammatory Role of ROS-Sensitive AMP-Activated Protein Kinase in the Hypersensitivity of Lung Vagal C Fibers Induced by Intermittent Hypoxia in Rats. Front Physiol. 2016 Jun 27;7:263.
15Zhao JF, Shyue SK, Kou YR, Lu TM, Lee TS. Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation. Int J Biol Sci. 2016 May 25;12(7):812-23.
16Chan MC, Tseng JS, Hsu KH, Shih SJ, Yi CY, Wu CL, Kou YR*. A minimum blood glucose value less than or equal to 120 mg/dL under glycemic control is associated with increased 14-day mortality in nondiabetic intensive care unit patients with sepsis and stress hyperglycemia. J Crit Care. 2016 Aug;34:69-73.
17Chan MC, Lin CH, Kou YR*. Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study. Int J Chron Obstruct Pulmon Dis. 2016 May 18;11:1053-9.
18Yang CH, Zhuang WL, Shen YJ, Lai CJ, Kou YR*. NADPH Oxidase-Derived ROS Induced by Chronic Intermittent Hypoxia Mediates Hypersensitivity of Lung Vagal C Fibers in Rats. Front Physiol. 2016 May 9;7:166.
19Yu YB, Su KH, Kou YR, Guo BC, Lee KI, Wei J, Lee TS. Role of transient receptor potential vanilloid 1 in regulating erythropoietin-induced activation of endothelial nitric oxide synthase. Acta Physiol (Oxf). 2017 Feb;219(2):465-477.
20Tseng YH, Ko HK, Tseng YC, Lin YH, Kou YR*. Atrial Fibrillation on Intensive Care Unit Admission Independently Increases the Risk of Weaning Failure in Nonheart Failure Mechanically Ventilated Patients in a Medical Intensive Care Unit: A Retrospective Case-Control Study. Medicine (Baltimore). 2016 May;95(20):e3744.
21
Lin CH, Jeng MJ, Kuo BI, Kou YR*. Effects of Surfactant Lavage Combined With Intratracheal Budesonide Instillation on Meconium-Injured Piglet Lungs. Pediatr Crit Care Med. 2016 Jun;17(6):e287-95.
22Pan SW, Kou YR, Hu TM, Wu YC, Lee YC, Feng JY, Su WJ. Assessment of latent tuberculosis infection in psychiatric inpatients: A survey after tuberculosis outbreaks. J Microbiol Immunol Infect. 2016 Aug;49(4):575-83.
23Zhao JF, Hsiao SH, Hsu MH, Pao KC, Kou YR, Shyue SK, Lee TS. Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice. Arch Toxicol. 2016 Jan;90(1):181-90.

五年內執行計畫

排 序 編 號 年 度計畫名稱單 位計 畫 期 間
12019肺阻塞合併胃食道逆流患者之氣道發炎: 膽酸嗆入之角色及膽酸與自毒素-溶血磷脂酸發炎路徑之聯結科技部2019/08/01~2020/07/31
22018由香煙煙霧所誘導的肺非對稱二甲基精氨酸可促進支氣管周圍纖維化及肺內皮細胞功能障礙並加速動脈粥樣硬化的形成:活體及離體的研究科技部2018/08/01~2021/07/31
32017探討自毒素-溶血磷脂酸路徑機轉在香菸刺激引起氣道發炎之角色-以鼠肺切片進行之研究科技部2017/08/01~2018/07/31
42016比較類固醇合併長效乙二型作用劑或長效乙二型作用劑合併長效抗毒蕈鹼劑在香菸萃取物刺激後的支氣管收縮與發炎反應之療效-以鼠肺切片進行之研究科技部2016/08/01~2017/07/31
52015香煙及薄荷香煙刺激肺細胞的非神精性瞬態電壓感受器陽離子通道M類第8型導致肺發炎及肺氣腫科技部2015/08/01~2018/07/31

實驗室成員

職稱/學位姓名
實驗室畢業生(博士班)陳惠芳、許添桓、賴靜蓉、林佑穗、何青吟、邊苗瑛、黃品勳、阮 婷、楊幼蘭、劉博侖、蔡玟蕙、李鴻福、柯信國、志學、楊昌寰、林鈺容、蕭逸涵、曾敬閔、曹珮真、吳崑明、詹明澄、王友明、余文光、蘇剛正
實驗室畢業生(碩士班)賴靜蓉、王卿瑤、張宏州、楊幼蘭、王春美、吳孟娟、林 澂、林瑞龍、劉育如、葉宏莉、翁維晟、徐秋玲、翁許庭、劉靜怡、林均蓉、王禎瑩、李智傑、張琮銘、王心怡、彭若芸、郭妍伶、鄒喬婷、何欣霓

實驗室活動

研究方向

主要的研究興趣是:

  1. 肺細胞發炎反應與凋亡的調控-以細胞培養、各種蛋白質定量、免疫染色、PCR、微陣列基因分析、基因轉殖等分子細胞生物學的技術進行研究。用上皮、血管內皮、巨噬細胞等肺細胞為研究題材。
  2. 多種肺損傷與肺發炎的成因與治療-以各種蛋白質定量、免疫染色、PCR、組織切片等方法進行研究。用大鼠與小鼠為研究題材。
  3. 急重症醫學及呼吸治療-以呼吸生理訊號及肺功能機械學測量、各種蛋白質定量、免疫染色、PCR、組織切片等方法進行研究。用大鼠與小鼠為研究題材,並操作人體實驗。
  4. 醫學流行病學及臨床醫學研究