陳政育
專任教授
(O) 02-2826-7083 / (Lab) 02-2826-7000 Ext.
nycutycchen@nycu.edu.tw
離子通道生理學
學歷
| 年度 | 學校名稱 | 學位 |
|---|---|---|
| 1994 | 約翰霍普金斯大學醫學院 | 博士 |
| 1986 | 國立陽明醫學院醫學系 | 學士 |
經歷
| 年度 | 服務機關名稱 | 單位 | 職務 |
|---|---|---|---|
| 1994 | 布蘭戴斯大學，沃爾瑟姆 | 研究員 | |
| 1984 | 國立陽明醫學院/台北榮民總醫院 | 實習醫師 |
代表著作
| 排序編號 | 著作名稱 |
|---|---|
| 1 | Fu SJ, Hu MC, Peng YJ, Fang HY, Hsiao CT, Chen TY, Jeng CJ, Tang CY. CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells. 2020 May 26;9(6):1332. doi:10.3390/cells9061332. PMID:32466489. |
| 2 | Nguyen DM, Chen LS, Jeng G, Yu WP, Chen TY. Cobalt ion interaction with TMEM16A calcium-activated chloride channel: Inhibition and potentiation. PLoS One. 2020 Apr 17;15(4):e0231812. doi:10.1371/journal.pone.0231812. PMID:32302365. |
| 3 | Xu P, Choo YM, Chen Z, Zeng F, Tan K, Chen TY, Cornel AJ, Liu N, Leal WS. Odorant Inhibition in Mosquito Olfaction. iScience. 2019 Sep 27;19:25-38. doi:10.1016/j.isci.2019.07.008. Epub 2019 Jul 12. PMID:31349189. |
| 4 | Nguyen DM, Chen LS, Yu WP, Chen TY. Comparison of ion transport determinants between a TMEM16 chloride channel and phospholipid scramblase. J Gen Physiol. 2019 Apr 1;151(4):518-531. doi:10.1085/jgp.201812270. Epub 2019 Jan 22. PMID:30670476. |
| 5 | Peng YJ, Lee YC, Fu SJ, Chien YC, Liao YF, Chen TY, Jeng CJ, Tang CY. FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane. Int J Mol Sci. 2018 Nov 28;19(12):3783. doi:10.3390/ijms19123783. PMID:30487393. |
| 6 | O’Halloran DM, Altshuler-Keylin S, Zhang XD, He C, Morales-Phan C, Yu Y, Kaye JA, Brueggemann C, Chen TY, L’Etoile ND. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Sci Rep. 2017 Mar 13;7(1):169. doi:10.1038/s41598-017-00126-7. PMID:28279024. |
| 7 | Jeng G, Aggarwal M, Yu WP, Chen TY. Independent activation of distinct pores in dimeric TMEM16A channels. J Gen Physiol. 2016 Nov;148(5):393-404. doi:10.1085/jgp.201611651. Epub 2016 Oct 17. PMID:27799319. |
| 8 | Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Sci Rep. 2016 Sep 1;6:32444. doi:10.1038/srep32444. PMID:27580824. |
| 9 | Riisager A, de Paoli FV, Yu WP, Pedersen TH, Chen TY, Nielsen OB. Protein kinase C-dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating. J Physiol. 2016 Jun 15;594(12):3391-406. doi:10.1113/JP271556. Epub 2016 Mar 20. PMID:26857341. |
| 10 | Yu Y, Tsai MF, Yu WP, Chen TY. Modulation of the slow/common gating of CLC channels by intracellular cadmium. J Gen Physiol. 2015 Dec;146(6):495-508. doi:10.1085/jgp.201511413. PMID:26621774. |
五年內執行計畫
| 編號 | 年 分 | 計畫名稱 | 單 位 | 計畫期間 |
|---|---|---|---|---|
實驗室成員
| 職稱/學位 | 姓名 |
|---|---|
實驗室活動
研究方向
Dr. Chen’s long-term interest is to understand structures, functions, and physiological roles of a class of transmembrane proteins called ion channels. These proteins control ion fluxes across cell membranes, and in doing so maintain normal physiological functions, such as conduction of nerve impulses, secretion of hormones and neurotransmitters, and maintaining cardiac rhythm. His recent work has been focused on two types of ion channels, the CLC chloride channels (CLC, for Cl- Channels) and cyclic nucleotide-gated (CNG) channels.