阮琪昌

專任教授

02-2826-7085

ccjuan@nycu.edu.tw

代謝生理學、分子內分泌學、脂肪細胞生理學

學歷

年度學校名稱學位
1991東海大學生物學系學士
1993國立陽明大學生理學研究所碩士
1998國立陽明大學生理學研究所博士

經歷

年度服務機關名稱單位職務
2016-2022國立陽明大學生理學科暨研究所科主任/所長
2009-迄今臺北市立聯合醫院教研部兼任研究員
2016-2018國立陽明大學總務處副總務長
2015-2016國立陽明大學實驗動物照護及使用委員會主任委員
2009-2016國立陽明大學醫學院醫學系副系主任
2008-2009國立陽明大學生理學研究所教授且兼任所長
2005-2008國立陽明大學生理學研究所副教授
2003-2005國立陽明大學生理學研究所助理教授
1998-2003台北榮民總醫院教學研究部博士後研究

代表著作

排序編號著作名稱
1Nitric Oxide Mobilizes Intracellular Zn 2+ via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation
2Chen CC, Kuo YC, How CK, Juan CC. Long-term Aerobic Exercise Training-induced Anti-inflammatory Response and Mechanisms: Focusing on the Toll-like Receptor 4 Signaling Pathway. Chin J Physiol., 2020. (Revision)
3Chen SP, Chang YA, Chou CH, Juan CC, Lee HS, Chen LK, Wu PC, Wang YF, Fuh JL, Lirng JF, Ducros A, Huang HD, Wang SJ. Pathogenic Role of microRNAs in Reversible Cerebral Vasoconstriction Syndrome (Manuscript # ANA-20-1456). Ann Neurol., 2020. (Accepted)
4Seow KM, Chang YW, Chen KH, Juan CC, Huang CY, Lin LT, Tsui KH, Chen YJ, Lee WL, Wang PH. (2020, Oct). Molecular Mechanisms of Laparoscopic Ovarian Drilling and Its Therapeutic Effects in Polycystic Ovary Syndrome. International journal of molecular sciences, 21(21):E8147.
5Juan CC, Li LH, Hou SK, Liu PS, Kao WF, Chiu YH, How CK (2020, Jul). Expression of ABC transporter and scavenger receptor mRNAs in PBMCs in 100-km ultramarathon runners. European journal of clinical investigation, e13365.
6Chiu CF , Chu LW , Liao IC , Simanjuntak Y , Lin YL , Juan CC , Ping YH (2020). The Mechanism of the Zika Virus Crossing the Placental Barrier and the Blood-Brain Barrier. Frontiers in microbiology, 11:214.
7Wu LY, Chen CW, Chen LK, Chou HY, Chang CL, Juan CC(2019, Sep). Curcumin Attenuates Adipogenesis by Inducing Preadipocyte Apoptosis and Inhibiting Adipocyte Differentiation. Nutrients, 11(10). pii: E2307. MOST 98-2321-B-010-005.
8Wu LY, Chen CW, Chen LK, Chou HY, Chang CL, Juan CC(2019, Sep). Curcumin Attenuates Adipogenesis by Inducing Preadipocyte Apoptosis and Inhibiting Adipocyte Differentiation. Nutrients, 11(10). pii: E2307. MOST 98-2321-B-010-005.
9Chien HC, Chan PC, Tu CC, Day YJ, Hung LM, Juan CC, Tian YF, Hsieh PS. (2018, Oct). Importance of PLC-Dependent PI3K/AKT and AMPK Signaling in RANTES/CCR5 Mediated Macrophage Chemotaxis. The Chinese journal of physiology, 61(5):266-279.
10Seow KM, Ting CH, Huang SW, Ho LT, Juan CC. (2018, Oct). The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome. Taiwanese journal of obstetrics & gynecology, 57(5):696-704.
11Chen JY, Jian DY, Lien CC, Lin YT, Ting CH, Chen LK, Hsu TC, Huang HM, Wu YT, Kuan TT, Chao YW, Wu LY, Huang SW, Juan CC. Adipocytes play an etiological role in the podocytopathy of high-fat diet-fed rats. J Endocrinol. 231: 109-120, 2016.
12Huang YH, Jian DY, Lien CC, Juan CC. Short-Term Hypoxia-Induced Inhibition of Adipogenesis and Enhancement of Insulin Sensitivity in 3T3-L1 Adipocytes Adaptive Medicine 8: 12-23, 2016.
13Lin YT, Jian DY, Kwok CF, Ho LT, Juan CC. Visfatin Promotes Foam Cell Formation by Dysregulating Cd36, Sra, Abca1 and Abcg1 Expression in Raw264.7 Macrophages. Shock. 45: 460-468, 2016.
14Lien cc, Jiang JL, Jian DY, Kwok CF, Ho LT, Juan CC. Chronic endothelin-1 infusion causes adipocyte hyperplasia in rats. Obesity. 24: 643-53, 2016.
15How CK, Hou SK, Chen LK, Yang CM, Huang HH, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC. Induced pluripotent stem cells alleviate lung injury from mesenteric ischemia-reperfusion. J Trauma Acute Care Surg. 79: 592-601, 2015.
16Chang CJ, Jian DY, Lin MW, Zhao JZ, Ho LT, Juan CC. Evidence in Obese Children: Greater Contribution of Hyperlipidemia than Those of Obesity-Inflammation and Insulin Sensitivity. PLoS One. 10: e0125935, 2015.
17Juan CC, Chen KH, Wang PH, Hwang JL, Seow KM. Endocannabinoid system activation might be associated to insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 104: 200-206, 2015.
18Lin YJ, Juan CC, Kwok CF, Hsu YP, Shih KC, Chen CC, Ho LT. Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome. Biochem Biophys Res Commun. 460: 497-503, 2015.
19How CK, Hou SK, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC. Expression profile of MicroRNAs in gram-negative bacterial sepsis. Shock. 43: 121-127, 2015.
20Wei TY, Hsia JY, Chiu SC, Su LJ, Juan CC (Co-first author), Lee YC, Chen JM, Chou HY, Huang JY, Huang HM, Yu CT. Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis. Cell Signal. 26: 2940-2950, 2014.
21Lin YJ, Kwok CF, Juan CC, Hsu YP, Shih KC, Chen CC, Ho LT. Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor. Biochem Biophys Res Commun. 451: 263-269, 2014.
22Tang YC, Liu CW, Chang HH, Juan CC, Kuo YC, Kao CC, Huang YM, Kao YH. Endothelin-1 stimulates resistin gene expression. Endocrinology. 155: 854-864, 2014.
23Chuang TY, Chang FY, Juan CC, Wang PS. Adaptive Roles of Adiponectin and Resistin in Cardiovascular Diseases. Adaptive Medicine 5: 21-28, 2013.
24Ho LT, Hsu YP, Hsiao CF, Ting CT, Shih KC, Chuang LM, Masaki K, Grove J, Quertermous T, Juan CC, Lin MW, Chiang SC, Chen YD. Endothelin Type A Receptor Genotype is a Determinant of Quantitative Traits of Metabolic Syndrome in Asian Hypertensive Families: A SAPPHIRe Study. Front Endocrinol (Lausanne). 4:172, 2013.
25Jian DY, Chao YW, Ting CH, Huang SW, Chang CF, Juan CC, Chen JY. Losartan ameliorates renal injury, hypertension, and adipocytokine imbalance in 5/6 nephrectomized rats. Eur J Pharmacol.709:85-92, 2013.
26Seow KM, Lin YH, Wang PH, Hwang JL, Ho LT, Juan CC. Aquaglyceroporin-7 overexpression in women with the polycystic ovary syndrome. Gynecol Obstet Invest. 75: 126-131, 2013.
27How CK, Chien Y, Yang KY, Shih HC, Juan CC, Yang YP, Chiou GY, Huang PI, Chang YL, Chen LK, Wang CY, Hsu HS, Chiou SH, Lee CH. Induced pluripotent stem cells mediate the release of interferon gamma-induced protein 10 and alleviate bleomycin-induced lung inflammation and fibrosis. Shock. 39: 261-270, 2013.
28Seow KM, Lee JL, Doong ML, Huang SW, Hwang JL, Huang WJ, Chang FY, Ho LT, Juan CC.  Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats. J Endocrinol. 216: 307-314, 2013.
29Chen CY, Ho LT, Yang FY, Juan CC. Au LC. Prunellae Spica extract contains antagonists for human endothelin receptors. Am J Chin Med. 41: 85-98, 2013.
30Liu TY, Chen CY, Juan CC. , Au LC. Coding region of adiponectin contains a silent intron reactivated by the adjacent intervening sequence of vector. Plasmid. 69(1):67-71, 2013.
31Wei TY, Juan CC (Co-first author), Hisa JY, Su LJ, Lee YC, Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, Liu KL, Yu CT. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 103: 1640-1650, 2012.
32Seow KM, Juan CC, Wang PH, Ho LT, Hwang JL. Expression levels of vascular cell adhesion molecule-1 in young and nonobese women with polycystic ovary syndrome. Gynecol Obstet Invest. 73: 236-241, 2012.
33Chai SP, Juan CC, Kao PH, Wang DH, Fong JC. Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic AMP in adipocytes. Int J Obes (Lond). 37: 197-203, 2013.
34Seow KM, Hwang JL, Wang PH, Ho LT, Juan CC.  Expression of visfatin mRNA in peripheral blood mononuclear cells is not correlated with visfatin mRNA in omental adipose tissue in women with polycystic ovary syndrome. Hum Reprod. 26: 2869-2873, 2011.
35Chuang TY, Au LC, Wang LC, Ho LT, Yang DM, Juan CC.Potential effect of resistin on the ET-1-increased reactions of blood pressure in rats and Ca2+ signaling in vascular smooth muscle cells. J Cell Physiol. 227: 1610-1618, 2012.
36Huang PI, Chen YC, Chen LH, Juan CC, Ku HH, Wang ST, Chiou SH, Chiou GY, Chi CW, Hsu CC, Lee HC, Chen LK, Kao CL. PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells. J Atheroscler Thromb. 18: 966-980, 2011.
37Hsu WY, Chao YW, Tsai YL, Lien CC, Chang CF, Deng MC, Ho LT, Kwok CF, Juan CC. Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. J Cell Physiol. 226: 2181-2188, 2011.
38Seow KM, Lin YH, Hwang JL, Wang PH, Ho LT, Lin YH, Juan CC.  Expression levels of haem oxygenase-1 in the omental adipose tissue and peripheral blood mononuclear cells of women with polycystic ovary syndrome. Hum Reprod. 26: 431-437, 2011.
39Chang CL, Au LC, Huang SW, Fai Kwok C, Ho LT, Juan CC. Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation. Endocrinology. 152: 384-393, 2011.
40Seow KM, Tsai YL, Juan CC, Huang LW, Hwang JL, Ho LT. Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome. Gynecol Obstet Invest. 69: 51-56, 2010.

五年內執行計畫

排序編號年 度計畫名稱單 位計畫期間
012020水溶性環氧化物水解酶在肥胖相關代謝異常之病生理功能:造血重編程與腸道菌相之角色科技部2020/08/01~2023/07/31
022020飢餓素對促發炎巨噬細胞信號極化的調節作用亞陽計畫2020/01/01~2020/12/31
032019介白素-6 對3T3-L1 脂肪細胞中脂肪分解反應的調控機轉振陽計畫2019/01/01~2019/12/31
042019鋅離子運送蛋白在脂肪細胞分化的調節角色亞陽計畫2019/01/01~2019/12/31
052019FKBP51在高脂飲食代謝異常之胰島素阻抗與發炎反應中的角色(3/3) 科技部2019/08/01~2020/07/31
062018第一型血紅素氧化酶對脂肪細胞分化的調控機轉振陽計畫2018/01/01~2018/12/31
072018饑餓素對內皮功能的調節機制之探討亞陽計畫2018/01/01~2019/06/30
082017活化趨化因子受器CCR5對C2C12骨骼肌細胞上胰島素敏振陽計畫2017/01/01~2017/12/31
092017鋅離子在一氧化氮調控脂肪細胞分化的調節效應亞陽計畫2017/01/01~2017/12/31
102016心房利鈉胜?在動脈硬化發生過程中的調節機轉科技部
2016/08/01~2017/07/31

實驗室成員

職稱/學位姓名
研究助理林宜秀
博士班陳倫魁
碩士班陳玫君、羅雅旗、陳品蓁、丁彩瑜、古蕙慈、蕭立恩、李品萱
實驗室畢業生(博士班)連之嬋、林于婷、莊東岳、張芝綾
實驗室畢業生(碩士班)鄭力誠、張靜珊、黃偉智、官澤庭、吳少筠、許庭嘉、黃萱閔、黃太嫈、黃千瑜、楊程茗、黃建豪、吳宇庭、謝慧嫻、林彥廷、林晏如、簡登淵、莊舒涵、陳欣怡、劉書豪、羅晨綺、 丁靖恆、林于婷、劉子瑩、徐偉嚴、黃郁涵、連之嬋、江佳玲、莊東岳、張芝綾、賴盈秀

實驗室活動

研究方向

主要的研究興趣是(1)代謝症候群病理機轉的探討、(2)具血管活性因子對新陳代謝的影響、(3)重組蛋白質的表現及活性探討、(4)脂肪組織分泌之細胞因子在肥胖及胰島素抗拒症致病機轉中的角色探討、(5)藥物及保健食品的開發。實驗對象包括細胞、組織、小鼠以及大白鼠等。研究方法則涵蓋細胞生理學、內分泌學、生物化學以及分子生物學等相關技術的操作。