阮琪昌

專任教授

02-2826-7085

ccjuan@nycu.edu.tw

代謝生理學、分子內分泌學、脂肪細胞生理學

學歷

年度學校名稱學位
1991東海大學生物學系學士
1993國立陽明大學生理學研究所碩士
1998國立陽明大學生理學研究所博士

經歷

年度服務機關名稱單位職務
2024-迄今國立陽明交通大學醫學院副院長
2016-2022國立陽明大學生理學科暨研究所科主任/所長
2009-迄今臺北市立聯合醫院教研部兼任研究員
2016-2018國立陽明大學總務處副總務長
2015-2016國立陽明大學實驗動物照護及使用委員會主任委員
2009-2024國立陽明大學醫學院醫學系副系主任
2008-2009國立陽明大學生理學研究所教授且兼任所長
2008-迄今國立陽明大學生理學研究所教授
2005-2008國立陽明大學生理學研究所副教授
2003-2005國立陽明大學生理學研究所助理教授
1998-2003台北榮民總醫院教學研究部博士後研究

代表著作

排序編號著作名稱
1Yu Liu S, Chen LK, Chung YT, Chen CW, Wu GL, Chang YC, Chen PR, Chang YI, Lin HF, Wu LY, Juan CC. (2024, Sep). Glucosamine inhibits myoblast proliferation and differentiation, and stimulates myotube atrophy through distinct signal pathways. The Journal of nutritional biochemistry, Online ahead of print. 本人為通訊作者.
2Liu SY, Chen LK, Jhong YT, Chen CW, Hsiao LE, Ku HC, Lee PH, Hwang GS, Juan CC (2024, Jun). Endothelin-1 impairs skeletal muscle myogenesis and development via ETB receptors and p38 MAPK signaling pathway. Clinical science (London, England : 1979), 138(12):711-723. 本人為通訊作者.
3I-Shen Huang, Li-Hua Li, Wei-Jen Chen, Chi-Chang Juan, William J. Huang. (2024, Apr). Intratesticular testosterone and its precursors among azoospermic men: A pilot study. World Journal of Men’s Health, Online ahead of print. 本人為通訊作者.
4Chen CW, Chen LK, Chung YT, Liu SY, Chen SW, Chang YI, Hsieh PS, Juan CC (2023, Dec). Cysteine-cysteine Chemokine Receptor Type 5 Plays a Critical Role in Exercise Performance by Regulating Mitochondrial Content in Skeletal Muscle. Inflammation, 46(6):2089-2101. 本人為通訊作者.
5Huang IS, Li LH, Chen WJ, Huang EY, Juan CC, Huang WJ. (2023, Aug). Proteomic Analysis of Testicular Interstitial Fluid in Men with Azoospermia. European urology open science, 54:88-96. 本人為通訊作者.
6Huang IS, Chen WJ, Wang ZL, Li LH, Chen YK, Wu YL, Brannigan RE, Juan CC, Huang WJ. (2023, Feb). The impact of low-intensity extracorporeal shock waves on testicular spermatogenesis demonstrated in a rat model. Journal of the Chinese Medical Association: JCMA, 86(2):197-206.
7Li LH, Hou SK, Chen CT, Chang YI, Kao WF, Chiu YH, Juan CC, How CK (2023, Jan). Effect of ultramarathon running on iron metabolism. Journal of the Chinese Medical Association, 86(1):80-87. 本人為通訊作者.
8Liao TC, Huang JP, Tsai YT, Shih WC, Juan CC, Hsieh PS, Hung LM, Yu CL. (2022, Oct). Granulocytic MDSC with Deficient CCR5 Alleviates Lipogenesis and Inflammation in Nonalcoholic Fatty Liver Disease. International journal of molecular sciences, 23(21):13048.
9Chen CW, Chen LK, Huang TY, Yang DM, Liu SY, Tsai PJ, Chen TH, Lin HF, Juan CC. (2022, May). Nitric oxide mobilizes intracellular Zn2+ via the GC/cGMP/PKG signaling pathway and stimulates adipocyte differentiation. International Journal of Molecular Sciences, 23(10):5488. 本人為通訊作者.
10Lien CC, Yin WH, Yang DM, Chen LK, Chen CW, Liu SY, Kwok CF, Ho LT, Juan CC (2022, Feb). Endothelin-1 induces lipolysis through activation of the GC/cGMP/Ca 2+/ERK/CaMKIII pathway in 3T3-L1 adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids , 1867(2):159071. 本人為通訊作者.
11Seow KM, Liu PS, Chen KH, Chen CW, Chen LK, Ho CH, Hwang JL, Wang PH, Juan CC (2021, Dec). Cysteine–Cysteine motif chemokine receptor 5 expression in letrozole-induced polycystic ovary syndrome mice. International Journal of Molecular Sciences, 23(1):134. 本人為通訊作者.
12Lin EC, Chen SW, Chen LK, Lin TA, Wu YX, Juan CC, Chang YI (2021, Nov). Glucosamine Interferes with myelopoiesis and enhances the immunosuppressive activity of myeloid-derived suppressor cells. Frontiers in nutrition, 8:762363.
13Juan CC, Chen KH, Chen CW, Ho CH, Wang PH, Chen HS, Hwang JL, Lin YH, Seow KM (2021, Oct). Increased regulated on activation, normal T-cell expressed and secreted levels and cysteine-cysteine chemokine receptor 5 upregulation in omental adipose tissue and peripheral blood mononuclear cells are associated with testosterone level and insulin resistance in polycystic ovary syndrome. Fertil Steril, 116(4):1139-1146. 本人為第一作者.
14Chen SP, Chang YA, Chou CH, Juan CC, Lee HC, Chen LK, Wu PC, Wang YF, Fuh JL, Lirng JF, Ducros A, Huang HD, Wang SJ. (2021, Mar). Circulating microRNAs associated with Reversible Cerebral Vasoconstriction Syndrome. Annals of neurology, 89(3):459-473.
15Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH, Juan CC, Nguyen P, Cheng HM, Huo TI, Chiou SH, Chien S. (2021, Feb). METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium. Proceedings of the National Academy of Sciences of the United States of America, 118(7): e2025070118.
16Juan CC, Li LH, Hou SK, Liu PS, Kao WF, Chiu YH, How CK (2021, Feb). Expression of ABC transporter and scavenger receptor mRNAs in PBMCs in 100-km ultramarathon runners. European journal of clinical investigation, 51(2):e13365. 本人為第一作者.
17Chen CW, Ho CH, Seow KM, Juan CC (2021). Polycystic ovarian syndrome and chemokine cysteine-cysteine motif ligand 5. Adaptive Medicine, 13: 16-19. 本人為通訊作者.
18Chen CW, Kuo YC, How CK, Juan CC (2020, Dec). Long-term aerobic exercise training-induced anti-inflammatory response and mechanisms: Focusing on the toll-like receptor 4 signaling pathway. Chinese Journal of Physiology, 63(6):250-255. 本人為通訊作者.
19Seow KM, Chang YW, Chen KH, Juan CC, Huang CY, Lin LT, Tsui KH, Chen YJ, Lee WL, Wang PH (2020, Oct). Molecular mechanisms of laparoscopic ovarian drilling and its therapeutic effects in polycystic ovary syndrome. International journal of molecular sciences, 21(21):8147.
20Chiu CF, Chu LW, Liao IC, Yogy Simanjuntak, Lin YL, Juan CC, Ping YH (2020, Feb). The mechanism of the Zika virus crossing the placental barrier and the blood-brain barrier. Frontiers in microbiology, 11:214.
21Wu LY, Chen CW, Chen LK, Chou HY, Chang CL, Juan CC (2019, Sep). Curcumin attenuates adipogenesis by inducing preadipocyte apoptosis and inhibiting adipocyte differentiation. Nutrients, 11(10):2307. 本人為通訊作者.
22Lin YT, Chen LK, Jian DY, Hsu TC, Huang WC, Kuan TT, Wu SY, Kwok CF, Ho LT, Juan CC (2019). Visfatin promotes monocyte adhesion by upregulating ICAM-1 and VCAM-1 expression in endothelial cells via activation of p38-PI3K-Akt signaling and subsequent ROS production and IKK/NF-κB activation. Cellular physiology and biochemistry, 52(6):1398-1411. 本人為通訊作者.
23Chien HC, Chan PC, Tu CC, Day YJ, Hung LM, Juan CC, Tian YF, Hsieh PS. (2018, Oct). Importance of PLC-Dependent PI3K/AKT and AMPK signaling in RANTES/CCR5 mediated macrophage chemotaxis. The Chinese journal of physiology, 61(5):266-279.
24Seow KM, Ting CH, Huang SW, Ho LT, Juan CC. (2018, Oct). The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome. Taiwanese journal of obstetrics & gynecology, 57(5):696-704.
25Chen JY, Jian DY, Lien CC, Lin YT, Ting CH, Chen LK, Hsu TC, Huang HM, Wu YT, Kuan TT, Chao YW, Wu LY, Huang SW, Juan CC. (2016, Aug). Adipocytes play an etiological role in the podocytopathy of high-fat diet-fed rats. The Journal of endocrinology, 231(5):109-120. 本人為通訊作者.
26Lin YT, Jian DY, Kwok CF, Ho LT, Juan CC. (2016, Apr). Visfatin promotes foam cell formation by dysregulating Cd36, Sra, Abca1 and Abcg1 expression in Raw264.7 macrophages. Shock, 45(4):460-8. 本人為通訊作者.
27Lien CC, Jiang JL, Jian DY, Kwok CF, Ho LT, Juan CC (2016, Mar). Chronic Endothelin-1 Infusion Causes Adipocyte Hyperplasia in Rats. Obesity, 24(3):643-53. 本人為通訊作者.
28How CK, Hou SK, Chen LK, Yang CM, Huang HH, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC (2015, Oct). Induced pluripotent stem cells alleviate lung injury from mesenteric ischemia-reperfusion. The journal of trauma and acute care surgery, 79(4):592-601. 本人為通訊作者. NSC 102-2314-B-075-038.
29Juan CC, Chen KH, Wang PH, Hwang JL, Seow KM. (2015, Jul). Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. Fertility and sterility, 104(1):200-6. 本人為第一作者.
30Chang CJ, Jian DY, Lin MW, Zhao JZ, Ho LT, Juan CC. (2015, May). Evidence in obese children: contribution of hyperlipidemia, obesity-inflammation, and insulin sensitivity. PLOS ONE, 10(5):e0125935. 本人為通訊作者.
31Lin YJ, Juan CC, Kwok CF, Hsu YP, Shih KC, Chen CC, Ho LT. (2015, May). Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome. Biochemical and biophysical research communications, 460(3):497-503.
32How CK, Hou SK, Shih HC, Huang MS, Chiou SH, Lee CH, Juan CC (2015, Feb). Expression Profile of MicroRNAs in Gram-Negative Bacterial Sepsis. Shock, 43(2):121-7. 本人為通訊作者.
33Wei TY, Hsia JY, Chiu SC, Su LJ, Juan CC, Lee YC, Chen JM, Chou HY, Huang JY, Huang HM, Yu CT (2014, Dec). Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis. Cellular signalling, 26(12):2940-50. MOST 95-2314-B-260-001. 本人為第一作者.
34Lin YJ, Kwok CF, Juan CC, Hsu YP, Shih KC, Chen CC, Ho LT (2014, Aug). Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor. Biochemical and biophysical research communications, 451(2):263-9.
35Tang YC, Liu CW, Chang HH, Juan CC, Kuo YC, Kao CC, Huang YM, Kao YH. (2014, Mar). Endothelin-1 stimulates resistin gene expression. Endocrinology, 155(3):854-64.
36Ho LT, Hsu YP, Hsiao CF, Ting CT, Shih KC, Chuang LM, Masaki K, Grove J, Quertermous T, Juan CC, Lin MW, Chiang SC, Chen YD. (2013, Nov). Endothelin Type A Receptor Genotype is a Determinant of Quantitative Traits of Metabolic Syndrome in Asian Hypertensive Families: A SAPPHIRe Study. Frontiers in endocrinology, 4:172.
37Jian DY, Chao YW, Ting CH, Huang SW, Chang CF, Juan CC, Chen JY. (2013, Jun). Losartan ameliorates renal injury, hypertension, and adipocytokine imbalance in 5/6 nephrectomized rats. European journal of pharmacology, 709:85-92. 本人為通訊作者.
38How CK, Chien Y, Yang KY, Shih HC, Juan CC, Yang YP, Chiou GY, Huang PI, Chang YL, Chen LK, Wang CY, Hsu HS, Chiou SH, Lee CH. (2013, Mar). Induced Pluripotent Stem Cells Mediate the Release of Interferon Gamma-Induced Protein 10 (IP-10) and Alleviate Bleomycin-Induced Lung Inflammation and Fibrosis. Shock, 39(3):261-270.
39Chai SP, Juan CC, Kao PH, Wang DH, Fong JC. (2013, Feb). Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic AMP in adipocytes. International journal of obesity, 37(2):197-203.
40Seow KM, Lee JL, Doong ML, Huang SW, Hwang JL, Huang WJ, Chang FY, Ho LT, Juan CC. (2013, Feb). Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats. The Journal of endocrinology, 216(3):307-314. 本人為通訊作者.
41Liu TY, Chen CY, Juan CC, Au LC. (2013, Jan). Coding region of adiponectin contains a silent intron reactivated by the adjacent intervening sequence of vector. Plasmid, 69(1):67-71. 本人為通訊作者.
42Chen CY, Ho LT, Yang FY, Juan CC, Au LC (2013). Prunellae Spica extract contains antagonists for human endothelin receptors. American Journal of Chinese Medicine, 41(1):85-98. 本人為通訊作者.
43Seow KM, Lin YH, Wang PH, Hwang JL, Ho LT, Juan CC. (2013). Aquaglyceroporin-7 Overexpression in Women with the Polycystic Ovary Syndrome. Gynecologic and obstetric investigation, 75(2):126-131. 本人為通訊作者.
44Wei TY, Juan CC, Hisa JY, Su LJ, Lee YC, Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, Liu KL, Yu CT. (2012, Sep). Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer science, 103(9):1640-1650. 本人為第一作者.
45Chuang TY, Au LC, Wang LC, Ho LT, Yang DM, Juan CC. (2012, Apr). Potential effect of resistin on the ET-1-increased reactions of blood pressure in rats and Ca2+ signaling in vascular smooth muscle cells. Journal of cellular physiology, 227(4):1610-1618. 本人為通訊作者.
46Seow KM, Juan CC, Wang PH, Ho LT, Hwang JL. (2012). Expression levels of vascular cell adhesion molecule-1 in young and nonobese women with polycystic ovary syndrome. Gynecologic and obstetric investigation, 73(3):236-241.
47Seow KM, Hwang JL, Wang PH, Ho LT, Juan CC. (2011, Oct). Expression of visfatin mRNA in peripheral blood mononuclear cells is not correlated with visfatin mRNA in omental adipose tissue in women with polycystic ovary syndrome. Human reproduction, 26(10):2869-2873. 本人為通訊作者.
48Hsu WY, Chao YW, Tsai YL, Lien CC, Chang CF, Deng MC, Ho LT, Kwok CF, Juan CC. (2011, Aug). Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. Journal of cellular physiology, 226(8):2181-2188. 本人為通訊作者.
49Chang CL, Au LC, Huang SW, Fai Kwok C, Ho LT, Juan CC. (2011, Feb). Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation. Endocrinology, 152(2):384-393. 本人為通訊作者.
50Seow KM, Lin YH, Hwang JL, Wang PH, Ho LT, Lin YH, Juan CC. (2011, Feb). Expression levels of haem oxygenase-1 in the omental adipose tissue and peripheral blood mononuclear cells of women with polycystic ovary syndrome. Human reproduction, 26(2):431-437. 本人為通訊作者.
51Huang PI, Chen YC, Chen LH, Juan CC, Ku HH, Wang ST, Chiou SH, Chiou GY, Chi CW, Hsu CC, Lee HC, Chen LK, Kao CL. (2011). PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells. Journal of atherosclerosis and thrombosis, 18(11):966-980.
52Seow KM, Tsai YL, Juan CC, Huang LW, Hwang JL, Ho LT. (2010). Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome. Gynecologic and obstetric investigation, 69(1):51-56.

五年內執行計畫

排序編號年 度計畫名稱單 位計畫期間
012020水溶性環氧化物水解酶在肥胖相關代謝異常之病生理功能:造血重編程與腸道菌相之角色科技部2020/08/01~2023/07/31
022020飢餓素對促發炎巨噬細胞信號極化的調節作用亞陽計畫2020/01/01~2020/12/31
032019介白素-6 對3T3-L1 脂肪細胞中脂肪分解反應的調控機轉振陽計畫2019/01/01~2019/12/31
042019鋅離子運送蛋白在脂肪細胞分化的調節角色亞陽計畫2019/01/01~2019/12/31
052019FKBP51在高脂飲食代謝異常之胰島素阻抗與發炎反應中的角色(3/3) 科技部2019/08/01~2020/07/31
062018第一型血紅素氧化酶對脂肪細胞分化的調控機轉振陽計畫2018/01/01~2018/12/31
072018饑餓素對內皮功能的調節機制之探討亞陽計畫2018/01/01~2019/06/30
082017活化趨化因子受器CCR5對C2C12骨骼肌細胞上胰島素敏振陽計畫2017/01/01~2017/12/31
092017鋅離子在一氧化氮調控脂肪細胞分化的調節效應亞陽計畫2017/01/01~2017/12/31
102016心房利鈉胜?在動脈硬化發生過程中的調節機轉科技部
2016/08/01~2017/07/31

實驗室成員

職稱/學位姓名
研究助理林宜秀
博士後研究員劉水育
博士班陳倫魁
碩士班古蕙慈、蕭立恩、李品萱、吳冠林、張以潔、朱語婕、陳捷妤
實驗室畢業生(博士班)劉水育、連之嬋、林于婷、莊東岳、張芝綾
實驗室畢業生(碩士班)陳玫君、羅雅旗、陳品蓁、丁彩瑜、鄭力誠、張靜珊、黃偉智、官澤庭、吳少筠、許庭嘉、黃萱閔、黃太嫈、黃千瑜、楊程茗、黃建豪、吳宇庭、謝慧嫻、林彥廷、林晏如、簡登淵、莊舒涵、陳欣怡、劉書豪、羅晨綺、 丁靖恆、林于婷、劉子瑩、徐偉嚴、黃郁涵、連之嬋、江佳玲、莊東岳、張芝綾、賴盈秀

實驗室活動

研究方向

主要的研究興趣是(1)代謝症候群病理機轉的探討、(2)具血管活性因子對新陳代謝的影響、(3)重組蛋白質的表現及活性探討、(4)脂肪組織分泌之細胞因子在肥胖及胰島素抗拒症致病機轉中的角色探討、(5)藥物及保健食品的開發。實驗對象包括細胞、組織、小鼠以及大白鼠等。研究方法則涵蓋細胞生理學、內分泌學、生物化學以及分子生物學等相關技術的操作。